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The statin study is almost worthless because they compare placebo to pravastatin?! The statins predominantly used in outpatient medicine in the US are atorvastatin and rosuvastatin. Both are much more effective at lowering LDL/increasing HDLs than pravastatin. They are particularly effective in reducing risk of cardiac events in certain groups (e.g., diabetes). You’ve been fooled into a bad take. Please correct or at least tell more of the story.

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Interesting, thank you for sharing that. I think the concern is with the other side effects of statins. Are there studies showing reduction in all-cause mortality with those particular interventions in those populations?

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In short, yes by many good studies. Also, the side effects you are thinking about (muscle pain and weakness) are falsely attributed to statin drugs roughly 9/10 times by patients.

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